Gillingham will welcome back defender Matt Lawrence, who has recovered from a hamstring injury.
Fellow defender John Nutter returns from suspension, while midfielder Danny Spiller should also make the squad.
Gillingham manager Andy Hessenthaler told BBC Radio Kent: "It's a tough game, we're on a bad run but I was pleased with the performance (against Crewe), but we've got to turn that into runs.
"Oxford are on a bad run, we've got a chance of going above them.
"The promotion dream isn't over, there are 90 points to get. There are teams over the years who've got off to a poor start and have kicked on."
Source: BBC Sport
Source: BBC Sport